Page 3 - Equi-infos

Hyaluronic acid

Sodium hyaluronate has been found present in the synovial fluid of all species studied. In humans it is also found in other soft connective tissues such as skin, umbilical cord, and vitreous humour as well as being present in lung, kidney, brain, and muscle tissues. Scientific understanding of the underlying properties of sodium hyaluronate started in 1934, when it was isolated from bovine vitreous humour Since the 1950s, the litterature concerning the potential therapeutic use of sodium hyaluronate in humans has grown.

The viscoelastic properties of synovial fluid in the joint are known to due to its sodium hyaluronate content. Changes in the lubricating properties of synovial fluid, lead to significant pain and loss of function.

In pathological conditions, due to acute and chronic inflammation, the synovial fluid no longer exhibits its normal rheological properties that protect the synovial tissue and cartilage from mechanical stress.

The concentration and molecular size